So you’re gonna take the word of folks who you know are lying to you about the source, as gospel when they tell you what they are selling you?
Then you’re gonna lie to some more folks to sell that shit on?
Cool story bro
Here’s another one…
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There are two separate studies I know of, The Edgewood studies by US gov on Humans , these took place in the late 60’s? You can find some data about these studies, but there are levels you can not access, or at least I have never be able to. If any of these studies were fatal, you are not going to find out.
In the 1940’s a group under the directives of a Scientist named Adams, researched the dimethyHeptyl THC analogues and these studies were done with dogs. Here is where you see reports of death …if I remember correctly. I’ll send a little GROK3 summary by DM to point you in the right direction. It is my recollection from reading these papers (numerous) that there was something wrong with some aspects of the data, so close inspection is necessary.
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Or if they catch you with plans to do it written down on say a website and hit you with conspiracy charges. I’ve known people who got sentenced to a dime without getting caught with ANYTHING.
But being a successful DJ/CEO this should be a part of the daily
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I think the recursive aspect here is that recreational use of “full agonists” does not end well.
there are people who “think” they might have access to THCP…If someone were to DAB a full agonist , say THCP, you can expect to be on the floor for 4-8 hrs unable to move. It would be obvious like a hit of Salvia, puts you down. So if you are puffing on something you think is THCP as a dab, and nothing like this is happening,…well your not smoking a full agonist.
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tbf it seems like one you can order on Temu
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I would put money there’s a hustler’s university charge on that bank statement
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do not insult my alma mater
Whatever they use hemp or not they get away with it calling it that and it gets you high? What else matters? Are you don’t licking boots and sucking nightsticks yet?
I don’t think you understand the ‘criminal conspiracy’ part of it. If you’re gonna do it - do it. Don’t leave the remnants of a bread factory in your wake. Less to do with gargling nightsticks more to do with enjoying what you make without forfeit. Yeah let’s enjoy our money for 30 seconds. Smart smart.
Can you not read information that’s in the public and then formulate your own CEO stylin’, profilin’, limousine riding, jet flying, kiss-stealing, wheelin’ n’ dealin’ plan? I know word ard hadr.
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i guess you don’t?
So been digging into this; the edgewood studies are fascinating, i found this book written by one of the higher level testers; James S. Ketchum.
from page 35- it describes some of the cannabinoid based compounds used ie; DMHP derivatives, and has some background on what a test would look like and how one was preformed. not much beyond that narrative stuff but an interesting look into an interesting time in American history.
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At least Adams tells you the subjects died.
If you look at the original paper describing THCP found in marijuana.
There is a diagram data showing locomotion data on a mouse after injection.
For a period of hours or so, there is a dot and the smallest squiggle …i.e., it didn’t go anywhere…A large dose of full agonist is really nothing like a large dose of partial agonist. The partial agonist also acts as a partial antagonist preventing the CB1 from full activation. THC activates about 10% of the CB1 action and blocks the other 90%. Think of the effect of 50-100 mg THC as a “baby dose”…a full dose of THCP in a vape pipe is going to put you down.
As Adams describes with dogs, after a period of non-movement , 8 hrs or so, it seems like full recovery 24 hrs later, and then a couple of days later the dog drops dead.
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I could see that being the case; if the patient survives the acute catatonic stage and CNS depression, then it has to trash the liver or kidneys or something and then its just a spiral from there.
Ill dig up the adams papers, thanks for the rabbit hole i find this stuff interesting.
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https://onlinelibrary.wiley.com/doi/10.1002/pcn5.70060
not sure if this has been posted here yet. the individual in the case study had a history of mental health issues; but still quite relevant for the thread.
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Perhaps the full agonists put the entire CB1 receptor display thoughout the CNS into a black hole of Beta- arrestin pathway action, internalization and loss of CB1 control. Total speculation …There seems to be a lot of psychiatric data from Europe on people who get into a downward spiral using full agonists. @roiplek might be able to enlighten us. There are even more problems when you block this receptor (CB1) as pointed out by the Rimonabant experience! It is amazing that Cannabinoids, THC in particular just stimulate this receptor in the right amount to make it pleasurable and safe as a partial agonist.
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i’m not really educated enough about the precise workings of the endocannabinoid system to have any authoritative statements to make, but if the timeline is correct, it might be massive downregulation of cannabinoid receptors that kicks in after 3 days and the entire system goes down the drain?
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this pub describes the process well, its quite fascinating; worth a read for sure if you haven’t already!
https://www.jbc.org/action/showPdf?pii=S0021-9258(22)00204-6 - Mechanistic origin of partial agonism of tetrahydrocannabinol for cannabinoid receptors
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Well it could be represented as specific radar plot.
I’ll read that article , thanks.
Quick look suggests I’ll get back to your in about one year…lol.
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(2019) 9:20335 | A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol | Scientific Reports
Origin paper on THCP isolation
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