It looks like I need to speed up my timeline, in order to protect our right to Δ8-THC…
Due to a little serendipity, then another several months of validation with a colleague, I have developed some very new, cutting edge science to make genuinely zero D9 compliant D8-THC in high yield and purity, straight from the reaction, using safer chemistry and simpler processing.
It is patent pending, but the only reason I am patenting it to protect its use for our community of processors, so Big Pharma cannot sue anyone or drive prices in a monopolized way, like they usually do! Therefore, it is extremely important to keep totally CONFIDENTIAL for at least 2 years!
To achieve the color shown:
○ No new equipment required ︎ Non-toxic, all GRAS chemistry
》 Short reaction time; 6 hours or less
~ No LLE washing required
° No cannabinoid distillation required
^ Safely scalable to any size
$ CBD to Δ8-THC yeild up to 97+%
★ Δ8-THC purity up to 99+%
θ True Zero Δ9-THC (No real or spurious peak artifacts) ︎ Patent pending to keep it available to our community; No Big Pharma lawsuits!
Any of you with isomerization labs and in-house or fast, free analytical capabilities who want to help secure this technology, please contact me!
All that above sounds real promising! Im happy for clean D8 to be on the market. Very good, carry on the work, hope the patent can pay off. Clean D8 is an important product that deserves a market right beside D9.
I am considering this to mean you are not seeing any isomer byproducts? I do need some convincing of this… can you provide the LC chromatograms from either Encore or AIT? Not sure if you have them but it would be very helpful to the marketing of your product, and really the only proof of no isomer impurities as these labs are not trying to quantify them so they would not appear on the final CoA.
I do not make or sell products, nor do I intend to make money from the patent… although I may need some licensing fees to pay for its defense from those who would abuse it.My only income is from teaching/consulting.
No problem boss, didnt mean to imply you were just selling a product. Again I would be very happy if your product (your process) lives up to what you are saying.
I still will need to see some raw chroma to ever think there is a process out there that makes clean D8. This is not on you I suppose to show but it would make me trust (or at least have hope for) clean D8 being on the market.
Also these impurities would come out on regular RPLC (what those labs were running)… if they aint there… you have a damn good process! You would not need chiral columns for this necessarily.
Yes, I am still waiting on chromatograms to come in from my clients and colleagues making the products. As you may know, it’s like pulling teeth to get the raw chromatograms and data from many labs… that’s why I would prefer someone with the instrumentation and skills to test in-house.
We need chiral columns to validate the presence or absence of chiral isomers, but you are correct: not necessarily for structural isomers. The FDA with the CFR requires all chiral drug compounds to be analyzed with isolation of all stereoisomers, diastereomers and enantiomers.THAT is the major reason why, for the past two or three years, I have been petitioning all compliance labs across the country to initiate chiral column screening and method development protocols for cannabinoid analysis! Our processors cannot afford to be dead in the water for months after such regulatory mandates come down from the government!
Taking “preparative” chromatography within the industry to a whole new level, I LOVE it! Great response and looking forward to developments in your method, @Photon_noir !
Not that I am probably any where close, but given your description I’m thinking ion exchange resins. I can’t really think of any other process that you wouldn’t want to distill after the reaction. BUT I’m no chemist, and I hold no answers!
Awesome job Good Sir!
Well that is a hell of a tall order IMO if you are asking them to change LC systems. I am only seeing SFC systems for running cannabinoids on chiral columns. https://www.waters.com/webassets/cms/library/docs/720005812en.pdf and I have looked at phenomenex and other vendors… no normal MPs, just supercritical CO2 for MP and organic.
Sorry but I am not about to do that in my lab anytime soon, I mean I am up for switching out mobile phases and columns but not going to do super critical CO2 as MP. And id guess most cannabis testing labs are not going to want to go through that trouble. But maybe universities or somebody already doing SFC?
The Waters UPC² was one of the first, so I can see why you might think it is only for SCO2 mp… but it’s not. There are chiral GC & HPLC columns, both partially & fully immobilized functionality, that could work with their typical solvent mobile phases. I promise!
The Waters product you referenced specifically uses SFC. This doesn’t mean that super critical CO2 is the exclusive MP for all chiral columns available.
I’m not speaking for anyone, but I don’t think that’s what @Photon_noir is saying at all.
︎ Non-toxic, all GRAS chemistry
︎ Patent pending to keep it available to our community; No Big Pharma lawsuits!
