In my environment, anhydrous ethanol is readily available.
Considering heat loss, I set the temperature of the stirrer’s hot plate to 100°C.
I would like to try a reaction with anhydrous ethanol + 35% HCL, what is the best time and concentration to use?
I am thinking of
Ethanol : 30g
HCL : 0.5g
CBD : 5g
In other words, dissolve 5g of CBD in about 0.5% HCl ethanol solution.
How about refluxing this for 2 hours to verify?
Doubt it ! Cheapest I have found in Europe
Is 232€ per liter with still ppb water content
As for hcl the gas ? Or dissolved in water
Might help if you tell me what you try to achieve
And what you want to use it for
Makes things a lot easier
I understand the aim is thc but 8 or 9 ?
At what scale what equipment is available ?
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HCL is 35% hydrate.
My goal is to isomerize as many percentages as possible.
Either 8 or 9 is fine.
Ideally, 8/9 should total 90%.
In my environment, p-tsa is a bit difficult to obtain.
Basic beakers and flasks, separating funnel, condenser
Heat magnetic stirrers
Rotary evaporator
And SPD if I decide to get one.
Ethanol on phosforic acid
Dry the ethanol with molecular sieves 3A
200 gr per liter
Take phosforic acid and dry it if all you are able to get is 85% in a normal oven until 15 %of it s weight has evaporated oven temp 110C
Make sure you place the phosforic in the middel of oven not on the botom where the heating element is
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Link to the simplest alkaline beam write up.
Distillation under the deepest vac you can attain will probably be preferable to roto once you start scaling up
What is this?
Advice
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It s a basic sop for cbd> thc conversion
Of all sop available this is the cleanest
In numbers 99% visible on a gc is very common
Color stays nice without much effort
Yes ethanol 96% is expensive but this works
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Thank you very much.
But in my country anhydrous ethanol is cheap.
A 500 ml of 99.5 vol% anhydrous ethanol costs about $10. You can buy it at pharmacies.
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Why don’t folks drink it?
(Some governments might achieve that with additives…)
I would expect this approach
Do you drink ethanol???
Maybe people in my country don’t like alcohol lol.
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This is the price for reagent grade anhydrous ethanol.
About $100 for a 3L.
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Does the phosphoric acid in this case need to be anhydrous?
I will try this soon.
CBD : 5g
Anhydrous ethanol : 10g
85% phosphoric acid : 1g(20% of CBD weight)
Reflux for 2 hours
Anhydrous ethanol 99.5% what’s the other 0.5% ? Probably water 0.5% water
On a liter is 5 ml. Wich equals to 500 ppm
In chemistry this is wET not even close se to dry
Pure ethanol that has now water needs a series of treatments t get rid of the water
Drying with molecular sieves only gets you into the 10 ppm range of dryness distilling over
Phosphorus pentoxide get s you in the 1 ppm area then
One filial distillation under very controled conditions hermetic glovebox (vacuumoven entry) n2 envirment you can get into the ppb
Of water content
That’s dry ethanol
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Use 2 grams of phosforic acid
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Thank you for the detailed explanation.
The explanation was very clear and I am now more familiar with chemistry.
I would add 2g of phosphoric acid.
Does “take phosphoric acid” mentioned in this method mean neutralizing it?