https://www.liebertpub.com/doi/pdf/10.1089/can.2023.0045?download=true
Haghdoost M, Brumar D, Geiling B, Brunstetter M, Bonn-Miller MO (2023) Chemistry, crystal structure, and in vitro receptor binding of D10-THC isomers, Cannabis and Cannabinoid Research 8:S1, S1–S10, DOI: 10.1089/can.2023.0045.
Interesting article on D10/CB1-CB2 pharmacological binding study’s…(D10 is just dud when it comes to recreations use). However , the paper is worth reading for details of acid/base induced isomerizations as well as new techniques utilized using “Path Hunter” assays which monitor GPCR signaling networks and bias signaling (CB1-CB2 receptor signaling/ how you get high or damaged stuff)
…in this case a rather interesting comparison of B-arrestin levels after CP55,940 full agonist vs D9 activation as a partial agonist. Gives you a better concept of “partial agonist”- action of D9-THC when viewed by B-arrestin AND why you might be advised to stay away from the recreational use of full agonists. Also notes that both the agonists and inverse agonists give rise to increased B-arresting levels (read text).
Another view of same phenomena:
Except Radar plot normalized to THC action on CB1 (purple)
Reference: Finlay DB, Manning JJ, Ibsen MS, Macdonald CE, Patel M, Javitch JA, Banister SD, Glass M. Do Toxic Synthetic Cannabinoid Receptor Agonists Have Signature in Vitro Activity Profiles? A Case Study of AMB-FUBINACA. ACS Chem Neurosci. 2019 Oct 16;10(10):4350-4360. doi: 10.1021/acschemneuro.9b00429. Epub 2019 Sep 24. PMID: 31513380; PMCID: PMC7365684.
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I’d absolutely love to see D9-THCp and D9-THCh plotted alongside those… Hopefully there’ll be some motivation for academia to look at it soon, as it’s… clinically relevant (aka available at the gas station)
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Keep and eye on the M. Glass lab , New Zealand (one of the authors of the above paper with Radar plots.). Recent review on toxicity of “synthetic cannabinoids”: Potential Implications of Multi-Drug Exposure with Synthetic Cannabinoids: A Scoping Review of Human Case Studies
Ref:
Potential Implications of Multi-Drug Exposure with Synthetic Cannabinoids: A Scoping Review of Human Case Studies
See more very interesting work :
ORCID
(Copy and paste)
Unfortunately, this group does not seem aware of toxicity work by Adams in the 1940s utilizing Dimethyl Heptyl analogues and his studies on dogs. Also seem unaware of bioweapons work, The Edgewood studies in the 1960’s , also using Dimethyl Heptyl analogues on Human volunteers . Adams reported something like Catatonia for 24+ hours, then dogs seemed to recover, and dropped dead three days later. The review is actually about the combination of drugs of abuse used in conjunctions with modern synthetic cannabinoids, so search parameters may well have ignored early work on Phorol-synthetics and variants.
Yes, I would like to “see” a radar plot of the Phorols as well. However, as I have pointed out previously, because consciousness involves “emergent” phenomena, there is no data plot to explain the experience, but may well be one to reveal the toxicity.
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Thank you 
I am suprised by the accidents of de fluor and non fluor noids of the same
Core
Wonder if the reason is that more noids of the non fluor core where distributed and thus the chance of accidents rise
But all in all yes some are mortal poisons at some point
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