Hey all, I’m not sure this is something that would work in application for the cannabis world, but I wanted to get some opinions or hear if anyone has already considered attempting this reaction with THCA or other cannabinoic acids.
The paper describes the use of copper salts and an aliphatic amine (TMEDA and HMTA seemed to work best as they are good σ-donors and are not sterically hindered) to catalyze the decarboxylation of aromatic compounds.
I was thinking that if done correctly this reaction might allow for the decarboxylation of THCA, CBDA or other cannabinoic acids in less time and at lower temperatures than traditional heating methods. This could potentially allow for increased production rates and higher quality product as heating can result in some degridation.
Let me know what y’all think.
cahiez2013.pdf (457.2 KB)