CBD to THC isomerization: How important are anhydrous acids in this SOP?

Hello There!

I want to do a simple isomerization of CBD to THC.
The SOP has been mentioned a few times on this forum already:

Dissolve 1g of CBD in 10ml 0.005molar H2SO4 in glacial acetic acid.

I initially thought I can create the acid solution by adding 0.5 ml of 0.1 molar H2SO4 to 9.5 ml of glacial acetic acid.
Since a lot of other SOPs underline the importance of anhydrous acids, I was wondering if my solution mentioned above would work since my H2SO4 is only 0.1 molar so a bit of water would act as an ampholyte.

I am new to this and would appreciate every little help :slight_smile:
Thanks for your attention.

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I’d suggest checking out ILL NYE CBD-D8 Conversion Master SOP

I don’t believe I’ve specifically seen an answer to your questions, but there are folks in there who can.

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Not really the most Thc favorable acids for the task
If you insist on h2so4 I would add some NACL
Making hcl in the process an acid of wich we know give s decent results

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Thank you very much for your answer!

I guess in this case I will use 30 %~ HCl (aq) and follow the formula from this paper:

I wasn’t aware that HCl produces better results than H2SO4, so again, thank you very much! :slight_smile:

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