Doesn’t matter if it’s an obvious and previously known process tho 
Not that you would know with all the sucking up you’re busy with
It does if you patent the chemical itself and the process around it 
He was the first one to make it so he patented it
Wrong.
Says the person who doesn’t even know who he is
God you’re so dumb
I know who he is. Even if not, what does it matter? Still doesn’t make your BS any more factual.
You know who he is now that you’ve been checked 
I dont think you realize
Dr mark > some theoretical chemist fake named roiplek
There’s a reason they call him " THE HYDROGENATOR" lol
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I’m still just lurking for a complete reaction mechanism 
@roiplek is kinda a dick but also kinda my hero.
Also, shout out to @DrMark on the clarification.
It’s insane to me that it’s taken this long to clarify the differences between anhydrous and anhydride.
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I don’t think there was any confusion as I was specifically talking about anhydride thats why I posted the synth.
Others have tried it with different results then what @roiplek predicts
Given that this isn’t a well established synthesis and that very small differences in apparatus and reactants can drastically influence the reaction—I have no doubt you’re correct.
He is also probably right about the relative differences in mechanism between anhydrous and anhydride.
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Hes incorrect on the losses though which is my point to this whole discussion
He keeps turning ppl away from trying things (that actually work!) Because in theory it doesn’t
Me and you both know chemistry doesn’t always work the way it’s supposed to in theory
I have to disagree here, a reaction with an anhydride is irreversible, whereas the reaction (in this case catalysis) with the anhydrous species is reversible.
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Try it and see what happens
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I’m sure I will at some point, but you see what I’m saying right? You will lose some CBD to irreversible tosylation before the catalytic mechanism can even go underway
Edit:
I want to clarify a few things so I don’t look like a total charlatan: when I say tosylation with an anhydride is irreversible, that’s not to say that the tosyl (or tosylate in this case…I think) is going to be attached to the CBD forever—but it’s purpose becomes as a leaving group instead of as a catalyst, meaning that it will attach to whatever carbon, and only “leave” that carbon when substituted with an adequate nucleophilic group. I think it’s an SN2 substitution.
In the case of anhydrous pTSA, there is no tosylation, at the (quoting @roiplek) c1 or c5 position. Instead the catalytic ring closure occurs without tosyl or tosylate formation.
@roiplek is this correct or am I missing something?
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@densone can chime in more on this then I can, all I know is he got great results with it which is why I said try it yourself
He never mentioned any large amount of cbd loss I feel like he would have mentioned that if it was a factor
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shits popping off and I have to read … are we still talking about ptsa anahydride?
All I can say is when mixed with toluene and reacted at room temp. It makes a considerable amount of d9 and almost only. I’d say with enough practice it could make some high d9. As for yield I don’t know… I’m stuck in science land and discovering process and wasting cbd for the good of science.
However, I’ve since started using a different catalyst that I like a lot more and feel like it gives me the best chance of making a very pure end product.
We will see … it’s a fucking rat race kids
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O shit @densone what’s the new catalyst u been messing wit?!! Can you share any breadcrumbs? HNY!
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Wouldn’t theory steer us towards stronger acids to make more D8 (because of the cyclization pathway) and a more weak acid for D9?
I ran poly with ethanol at 75c with no argon and reflexed for 2hours and got almost 60% D9, 20% D8, and (I believe) almost 10% CBD just f***ing off.
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Yassssss finally someone tried poly!
Was it 200 proof?
Try heptane next for me plz
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Happy New Year,
Gonna keep my mouth shut on this one till I make it work the way I want. Last thing I want is to send more people down a rabbit hole with me.
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