I know it wasn’t but thats what I took from it. Education is something that can be gained, intelligence is much more difficult bordering on impossible to gain. I have no problem being uneducated, because I enjoy the process of education.
I take offense when I think I am being called stupid cause thats just not true, and my ego is very attached to my slightly above average intelligence. I get that isn’t what you were saying either.
You often bug me, and you definitely have an abrasive personality, but I still like/respect you.
in my case, i’d say intelligence is the product of being curious along with learning from the outcomes of situations when you’ve been a little too curious so it should actually be curiosity that is hard to gain.
as you should, and while i don’t think i’m more stupid than the average person, i still pull off stupid shit all the time. you just gotta know what was stupid about it to improve on it next time.
I made up Nonohydrate as a joke, if that wasn’t obvious. The correct name for that compound is of course “p-Toluenesulfonic acid (anhydrous)”.
Which conditions do you want to apply the Na-tosylate to? Converting it to the acid would of course involve protonation with a stronger acid than PTSA itself.
Since Na-tosylate is not an acid, i don’t see how it would react at all - not even taking into account the solubility issues of it in organic solvents.
Yes, it’s anhydrous p-toluenesulfonic acid not the anhydride, lol. As previously mentioned, the mono hydrate is stable and can be weighed into toluene and then azeotrope the water away by stripping the toluene under vacuum. The monohydrate can also be dried by heating the monohydrate under vacuum but unless handled under Schlenk line, it will easily re-absorb ambient moisture from the air. The reason why water is an issue here is that it creates hydronium ion (H3O+) which equilibrates delta 9, the kinetic product to delta 8, the thermodynamic product. Order of addition and concentration/solvent effects also appear to have an impact on yield and selectivity. The shift of the vinylic proton resonance in delta 8 stands out in a window in the proton nmr spectrum making it a good tool to follow selectivity in the reaction. Hope that helps. Happy hunting cannabinoid chemists!
I think “stripping the toluene UNDER VACUUM” is not the way to go. Ptsa has a low solubility in toluene, you need toluenes high BP 110 to pull the water from ptsa (mp 106).
Also a schlenk line would be ideal. But you could make it work without one as long as your careful to keep it under inert atmosphere. So don’t be discouraged if you want to try this but don’t want to spend 500 on a schlenk.
Btw if the dude was such a smart person he’d know that what he “patented” isn’t really patentable due to it being an obvious process to make a compound known for decades.
The dude you are talking about is a master in hydrogenation s MASTER !!
His work will revolutionize the cannabis medical industry for years to come
His approach to isomerizing is far more complex than the average here and so are his yields making pharma grade end products
Feasible yields of 98.8 last I recall
As I said @densone has done it with great success which means you’re statement of
Isn’t true and if you would have tried this youd know it
How do I know you haven’t tried it? Because if you had you’d realize you’re wrong just like with your dumb statements about neutralizing and acid with a base. You didn’t even know it would cause an emulsion because you’ve never tried it xD
LOL the dude used a pressurized reactor when he could have done it at RT, ambient pressure and without molecular hydrogen… i don’t think i would call him a master, especially not if he thinks you need vacuum to azeotrope away some water
so it should actually be curiosity that is hard to gain.
