61% yield isn’t that great though
Maybe they’ll figure out how to get that higher
One of the catalysts yielded 82% d9 11%d8
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Toluene ptsa room temp 48 hours
82%d9 11% d8 according to the paper
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Sweet post, thank you KOTK
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82% is decent. Was the remaining 7% unreacted?
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Not sure, they were looking for d8,d9,d8isothc, and this other iso thc. Its not one of those
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I need to get my ACS journal access again…
Do you know what wt. % of pTSA they used relative to CBD?
Also, it looks like 24 h, RT, pTSA gave 82% 9 and 11% d8… 48 h shifted the reaction to the more stable d8.
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48 hours gave 82% d9 11% d8, 96 hours yielded 9% d9 89% d8
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2 mol per 1 mol CBD. Totally nuts if you ask me.
Also sadly, no direct comparison is possible between Table 2 entries 5 and 6, because they doubled the reaction time for the latter. Super annoying!
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I was just reading the image you posted. So 24 h + 24 h yielded the predominantly 9 weighted sample?
pTSA·H2O-Catalyzed Reactions (Table 2).
Conditions (Table 2, entry 5): CBD (318 mg, 1 mmol); solvent, anhydrous toluene (5 mL); T = RT; pTSA·H2O (386 mg, 2 mmol); reaction time, 48 h. Yields: Δ9-THC, 262 mg (82%); Δ8-THC, 34 mg (11%).
Wasn’t it @Photon_noir that was talking to @Roguelab about p-TSA in alkanes at RT?
Ah, yes:
So he had it figured out for a while already. That’s it for your SOP now, @Photon_noir 
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His d8 sop use hexane
I have a copy of it
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Shouldn’t make much of a difference, RT is RT.
I think it should be possible to cut down a lot on the p-TSA when replicating this
if using anhydrous p-TSA and rigorously drying the solvent.
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fucking nice find man, thanks!!!
Reminds me if publishing in grad school… reproducible? Maybe! Carefully controlled conditions? Sometimes!
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From isolate ? What purity is the starting material?
thats from high purity cbd isolate?
Thanks for the link. Note the paper’s “received” date was April 20… 
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