Ok so to scale the HHC production i need to find the best shortcut to THC
Althou several beads can get the job done
Wich one has the highest yield
At the best $
Amberlyst 15 yield 82%
Amberlyst 17 yield 73%
Sapo 35 78%
P tolueen sulfonic polystyrene 92% ($$$$)
So the theory is
Make thc in high yield 95+%
With a bead Wich will not release any reagent
In the alcohol solvent and once the beads are filtered out proceed with the hydrogenation
Another option I am contemplating is
Produce HCL gas on location and sparge treu a solvent that does not dissolve HCL gas
Doubt it will work thou and proceed to HHC
Question is how does hydrogenation function on alkane solvents ?
Are you looking for a high yield of D9 or just maximum conversion of CBD, therefore a mix of D8 and D9?
I tried a lot of different beads from Purolite.
Most of them are sulfonic acid activated. They give a good conversion in general, but the yield is “comparable” to a classic pTSA conversion. High affinity for d8. @Dr_Jebril may go more in depth here, since he found it to produce iso THC if I remember correct.
I think the best route for high D9 would be support bonded phosphoric acid. So far I did not found any. PuroLite has some beads with phosphonic acid, but I doubt they do the trick.
Since the thc is meant as precursor for HHC
The 9/8 does not matter
Having a high Thc yield is what counts since it should all be Hhc in the end and so far I have not found much difrance in starting with high thcD9 or high thcD8 as long as it is thc
So to avoid the washing the acid out process
From the cbd isomerization to thc
I like to find the right parameters and bead for the job
Thx and will do
Looking for the bead that makes D8 in highest yield @mitokid what would a hydrogenated iso-thc look like ?
Would the positions align to all Hhc ?
Or would a iso-thc or trans-thc for that matter all end up as a Hhc ?
Rabot hole here I come
You can definitely make HCl gas on site and then pass it through a bunch of drierite to clean it up. thing is you can’t use any metal connections or they’ll corrode like crazy
I’ve done a bunch of hydrogenations but never in an alkane solvent. Methanol/Ethanol with Pd/C were the go tos. Why do you ask if it can be done in alkanes? I thought the initial conversions were done in ethanol.
Thx for the info of HCL I am well aware of it s drawbacks great reagent all together
If I where to sparge hcl in an alcohol washing the acid out is a must since it dissolves well in alcohols back to square 1
Reason I am contemplating a difrent solvent
Alkane or tolueen
If D9 is favorite alcohols are a bummer
Main D9 solvents I use are hexane pentane or DCM with the pyrophoric reagents
I am sure you are a lot but I mean a lot beter versed than me in the chemistry but I hardly see much better yields using D8 or D9
Maybe other members can tell there findings @RockSteady@eyeworm@Psilisophical
All these product yield above 90% THCs (d8+iso-d8+small d9).
The d8 yields listed by @Roguelab are acurate.
The difference to 90% is roughly the iso-d8.
The same can be said regarding the classical route to d9 with the organometalic catalysis (70%d9+20%iso-d9)…
It is likely the case that most HHC is produce from delta 8 THC…
Or it would mean that classic employed hydrogenation route is in fact non steroselective, regardless of substrate.
It is also interesting to see that there seems to be no iso-HHC.
As if the iso-THCs would eventually turne into the same HHCs as THCs.
I did not though about combined yields when writing this.
In fact, following this, a mixture with 40% d9 and 67% d8 would yield 1:1 R/S.
Then anything leaning more and more toward d8 would slowly rise toward 1:2 R/S.
(e.g. 10% d9 + 90% d8 would yield 1:1.6 R/S).
re-edited: I made basic error in my calculation, which @mitokid corrected hereafter…