Had an interesting conversation with some of my European clients about HHC. As we know, higher potency is more desirable when purchasing HHC and having no heavy metals is equally as important.
This client in Spain brought up a chart showing that there are two HHC varients: 9R-HHC which is active and 9S-HHC which is inactive. My question is do all liters of HHC have this 1:1 (or close to a 1:1) ratio and does it matter? Does the inactive 9S HHC still have effects on the user?
I found this article on Leafly that touches on the subject. They state that the remediation process would essentially but to costly to justify. With that being said, I believe it implies that 9S does nothing for the user, since they touched on remediation/separation.
Please let me know your thoughts and once we get the info, I will write an informative article about it.
Is most d10 racemic in the same proportions? If d10 is skewed to one or the other, that would be a better starting point since the hydrogenation doesn’t have two options when saturating the planar double bond attached to the methyl group
Also I haven’t ran this reaction and probably never will, my hydrogenation is limited to 200mL flasks with a balloon many years ago. Can you push the products by running an ice cold reaction vs rt vs warm?
The 10-10a double bond is more hindered than both the d8 and d9 double bonds, possibly making hydrogenation more sluggish.
Facial selectivity may be much influenced by chirality at C9. This could be a good thing.
Hydrogen could be added either from the same side as the 6a hydrogen is pointing, making an unnatural cis ring junction. Hydrogen would have to be added from the other side to arrive at the natural trans configuration at the ring junction.
I think the last issue is the bigger one. I think that the predominant products will be the ones with a presumably inactive 6a-10a ring junction.