Absolutely possible, not clear why you would want to.
Terp profile would definitely suffer.
Sure, you coukd absolutely squish the results, but imo you would get better results if you left the heater off in your oven.
What temperature are you thinking?
Care to elaborate on why?
How are you planning to keep the water out of your vacuum pump?!?
Edit: survey says freezing your trichs, and precooling your vac oven are likely required.
See eg: Freeze Dryer Vs. Vacuum oven for drying ice water hash?