I dont “think” they are the same…never said they were
However both are covalent bonds
Both involve oxygen, wether bonded to carbon or hydrogen, where oxygen is more electronegativity in both arrangements, meaning there is a shift in electron density, resulting in a partial negative charge about the oxygen. Both arrangements that partially negative region is in a similar place. Oh I am sure if you really wanted to quantity the dipole moment of the the two you could, but goodness sake the point is both thc and cbd are pretty non-polar as a whole and youll want to use c18 column packing material to separate & elute them
I think the confusion may arise when I suggested I didn’t think the difference in magnitude of the polarity of the two groups was such that cbd would be better retained on a normal phase column
Well, you’re for sure on the right track, but you may want to look up oxygen hydrogen bonds, there’s a bit more to molecular polarity than pure electronegativity… As it turns out, hydrogen bonded to oxygen has a pretty strong partial positive charge and has no more electrons to cover it
You may be right - Id have to delve into the numbers. That being said…
I was a Chem major ‘back in the day’ and a large part of me loves the science, loves the experimentation, the bench work… I may end up regretting this zeal some time soon - hopefully not.
At the end if the day- its interest and not a small bit of pride that has me researching almost every chance I get outside of work. Which aint easy since… ahhh another story for another time.
Appreciate the discussion and help.
Still trying to figure out the best solvents / solvent gradients for rev phase. Have excess info on normal phase - but thats not helpful for this particular situation.
It’s a balance as THC-free existed solely due to laws. Once THC is allowed at higher levels, remediation and all associated equipment is immediately obsolete for this purpose.
The entry costs don’t justify the instability of the market for many.
What do you all think about the Interchim ITM-800 for reverse phase. Has anyone used on before? They claim it will cost 21cents per gram of oil to become t-free. T Free CBD.pdf (312.1 KB)
Well there is actually one other market factor driving this and that’s the consumer segment that cannot have any THC due to job-mandated drug screening. Perhaps that will change someday as well but I think that timeline is much longer. I’ve discussed this with more than one formulation lab as a legitimate concern they have for their products.
If the limit is raised to 1% it will likely invalidate testing and maybe force it ma widespread use to stop.
It depends on what the courts decide obviously, but if I can consume a federally legal substance, why would a urine test that can’t identify between the two be able to determine eligibility for employment.
Remediation equipment can be used to separate cannabinoids, and for pesticide remediation. Isolating hundreds of cannabinoids, not only THC, is very interesting.
