Methanol works hands down better than less polar solvents and I typically run methanol cut down even more polar with an addition of water. I can “winterize” without any freezer or cold by simply adding some water to the methanol and then pulling it past alumina. Methanol has its own handling characteristics but methanol is routineky used by young folks using remote control engines on cars and planes and such. Incidental exposure does not seem particularly harmful although I treat all solvents except water about the same. I avoid exposure but really nothing out of the ordinary. Methanol is particularly useful IF you elect to run a liquid to liquid extraction of the volatiles on the compound as a follow on technique. In that case methanol is the only solvent that works very well because traces of it left in compound will not impact the process like traces of ethanol or iso will.
However if you are not running LLE that needs methanol I find iso cut with water has its own advantages and is sort of a toss up. 