I could look into this more but the reason the loss of CO2 is so easy to perform from a chemical perspective is because it is a very “favorable” reaction. A very negative delta G in terms of gibbs free energy. Your body does a plethora of these decarboxylation/carboxylation reaction and this energy can be used to either create or consume ATP!
This may help, synthetic reactions for adding on carbon dioxide. Overall be pretty energy intensive and no way around that from what I can see.
wow. that does look like a whole bunch of ways to put the genie back in the bottle.
many of them seem to require starting points that look like synthetic challenges in and of themselves. none jump out at me as a trivial answer to the OP’s question.
I’ve certainly told the boss “nope, not happening” on at least one occasion.
Given that there are so few novel ideas these days, I would assume that if it was easily accomplished we’d have seen it on instagram already.
Could try removing any air/water from reaction and use high pressure while bleeding in CO2. Unfortunately or maybe fortunately the decarboxylation is so favorable it makes this step tough!
@Drjosh is this a trick you perform? Or teach others to perform?
Is it worth the effort? How about the price of admission?
for the crowd: Does the chemical synthesis performed move us from isolating a naturally occurring compound to manufacturing a controlled substance? Or are we there already the moment we add solvent to biomass?
@cyclopath, our industry is on the cusp of greatness. Hydrogenated cannibinoids, are being explored, other varyations as well. The key now for our development of products is the pharmacological understanding of these novel compounds. This is a great time to live and breathe!
I know the processes are different, I was elaborating on the recent progress we have made with these molecules. Hydrogenation is an example of transforming a naturally created compound that was isolated into a different form.
Is this manufacturing a controlled substance? Could be, probably, most likely is? That was my answer .
from a chemistry standpoint, saturating those double bonds to slow in-vivo degradation/elimination, combined with added sugar moieties to give water solubility seem like very reasonable tweaks. They also seem like crossing the line into the realm of big pharma as far as regulatory issues go.
Distillate is a good target to reintroduce the carboxyl group. Especially if all the cannabinoids can be isomerized back into d9 thc before hand.
Yeah?
I disagree, distillate would not be the best form, thc isolate would be the best assuming this is what we are trying to achieve in the end of the process is THCA. The reason for isolate over distillate is more control and you wont be carboxyling other molecules or causing side reactions from the harsh conditions needed to perform the reaction.