Cannabinoid Isomerization

I just noticed that I have collected a bunch of papers on cannabinoid isomerization. I wanted to drop them here together in case anyone else finds them useful.

USPTO 2004- CONVERSION OF CBD TO DELTA8-THC AND DELTA9-THC
CBD-to-THC.pdf (550.5 KB)

USPTO 2008- CONVERSION OF A8-CBD TO A9-THC
US7399872.pdf (489.6 KB)

USPTO 2014- PROCESS FOR PRODUCING AN EXTRACT CONTAINING TETRAHYDROCANNABINOL AND CANNABOOL FROM CANNABS PLANT MATERIAL AND CANNABIS EXTRACTS
Mueller 2014 Separation of Cannabinoids with CO2 and silica US20140248379A1.pdf (1.1 MB)

USPTO 1947- PREPARATION OF COMPOUNDS WITH MARIHUANA ACTIVITY
US2419936.pdf (639.1 KB)

Tetrahedron. 1946. Vol. 22, pp. 1481 to 148- HASHISH-VII’ THE ISOMERIZATION OF CANNABIDIOL TO TETRAHYDROCANNABINOLS
isomerization(1).pdf (559.3 KB)

Cannabis and Cannabinoid ResearchVolume 1.1, 2016- Identification of Psychoactive Degradants of Cannabidiolin Simulated Gastric and Physiological Fluid
can.2015.0004.pdf (1.3 MB)

Structure of Cannabidiol. VI. Isomerization of Cannabidiol to Tetrahydrocannabinol, a Physiologically Active Product. Conversion of Cannabidiol to Cannabinol
adams1940 iso.pdf (427.6 KB)

Structure of Cannabidiol, XII. Isomerization to Tetrahydrocannabinols
adams 1941.pdf (547.5 KB)

Kiselak TD, Koerber R, Verbeck GF, Synthetic Route Sourcing ofIllicit at Home Cannabidiol (CBD) Isomerization to Psychoactive Cannabinoids Using Ionmobility-coupled-LC-MS/MS,Forensic Science International(2020)
2020_110173_forsciint.pdf (2.3 MB)

Cannabidiol: an overview of some chemical andpharmacological aspects. Part I: chemical aspects
Detailed CBD to THC.pdf (239.0 KB)

Isolation, Synthesis And Structure DeterminationOf Cannabidiol Derivatives And Their CytotoxicActivities
Isolation, Synthesis And Structure Determination Of Cannabidiol Derivatives And Their Cytotoxic Activities.pdf (1.2 MB)

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thankyou very much :slight_smile:

from little things …

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Kind of proves what I said about the pigs following us like shit to a shovel but being so behind us
that they have no chance.

this one I found really interesting on how the CBD will oxidize to a quinone loosing one of its
phenol groups.

oh and of course unless I were to go with the alkyl aluminium I think adams had the best way back
in the 40’s :slight_smile:

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MARIHUANA- ROGER ADAMS Professor of Chemistry, University of Illinois Harvey Lecture, February 19, 1942
bullnyacadmed00560-0006.pdf (2.4 MB)

I don’t know the accuracy of any of this, but I thought this site was interesting:
CBD Isomerization

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Thanks for posting this!