Ya I’m doing well w crc and chromatography for purification seems very similar. I’ll probably stick w crc.
Lab Society is now Teledyne’s distributor for the hemp industry. They still don’t want to sell to medical/recreational cannabis (read: THC) customers, though.
I prefer a stationary phase column for separation for the following reasons:
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Significantly quicker “ready to go time”. There is much more information out there on separation of THC and CBD on your classic C18 (or other medium) stationary phase than there is on how to develop proper methods for separation on a CPC. Unless the end user has significant chromatography experience and understanding of physio-chemical interactions, then it would require much more time to get up and running.
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I believe that if you are trying to scale, my personal experience is that one CPC has too little throughput compared to how much you can separate with a column, especially if you hand pack your own columns. You will be able to get an equal or greater throughput compared to the CPC.
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Price is in favor of a stationary phase set-up, in my opinion. As someone mentioned, a brand new CPC goes for about 200 - 250K for the largest throughput model. For 200 to 250k you can have multiple columns ready to go for separation, especially if you go on the cheap side and just pack your own columns.
This is all just my personal preference. If they made a higher throughput CPC and already have the method development finished for you, then maybe it could compete for throughput.
Now, if you’re looking to do more than just separate THC from CBD, then I would definitely sing a different tune. I believe using the CPC to isolate multiple components from a single mixture is where it might have an edge over your classic stationary phase set-up, but for simple THC remediation, I don’t think it’s the best option.