SPD QUESTION - Reflux Column

I don’t see anyone using a reflux column. I was under the impression it was needed…Please advise… NewsFlash: A group of thugs just highjacked a viagra shipment from LAX! Be on the lookout for a gang of hardened criminals…


The vigereux (dimples) on the inside of the column provides some interference. Some people use a packed column (stainless scrubby or otherwise) to increase theoretical plates. You usually need to increase energy input/vacuum levels to balance the additional reflux. Also has the tendency to increase run times but also increase resolution.