This is exactly what Dr. Paula MacFie said during our interview. She uses the “First Knuckle Rule” for insertion and says that even decarboxylated/active THC is not psychoactive in huge doses with this method.
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yeah i cannot afford a consult for a personal project. I think i can figure it out from here.
cant be too hard. Take drugs; stick up butt
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She is so generous. I am confident she would help you. She uses Cacao butter for stability and bioavailability and I believe she uses an extract like RSO
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I am currently treating my wife with D9 suppositories. pm me for a first-hand account of results.
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Been studying on properly formulating suppositories for a hot minute to help with my crohns as well as a few patients asking for us to formulate one. When these do hit the market, I’ll be selling them at cost to patients and a penny to all our cancer patients
Here is my first one
200mg total goal
Cocoa butter base
D9 distillate
Myrcene
Pinene
The first batch is strictly for me to test out, I plan on making another batch after I feel a little more confident in the product. Testing one of these out tonight
If all works out, I plan on some colorful packaging and marketing just to to draw some attention and educate patients on why they might wanna go the suppository route.
Name we’re currently going with… “Boof Bombs”
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Using zaza style packaging on suppositories…
Genius.
We need cookies and supreme branded suppositories ASAP.
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I recommend a more water soluble base than cocoa butter which will melt and leak. You really don’t want a lipid base because you’ll already be constrained by the membrane’s ability to transport hydrophobic compounds with the API. Also don’t recommend adding terps to a suppository, you may get complaints of burning.
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I kinda figured which is why I’m testing the batch out myself first.
What would you recommend over the cocoa butter? Possibly glycerinated gelatin?
I’m afraid not allowed to tell you what we use. It is not glycerinated gelatine. Search your pharmaceutical excipients, you will find it
Fckin NDAs
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Form whence the phrase: you can stick that NDA up your arse!!!
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I’ve been doing some research on just that , I think I may know what you’re talking about!
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share with the class?
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So I did try one after my post since I went straight home. I can’t say there was discomfort due to the terpenes but there’s definitely something lol.
It’s only been about 3 hours but there were some noticeable effects I’m noting;
1: My normal stomach pain has eased tremendously
2: The constant pressure I have in my solar plexus has been slowly decreasing. I haven’t had that since I stopped taking Ativan about 5 years ago!
3: So far no psychoactive effects noted. I haven’t consumed anything all day specifically to test this out. I’m gonna give it another 2 hours before I cave in and take a dab
There are some changes definitely needed to dial in but it’s a start
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I narrowed it down originally to 2 things if it wasn’t gonna be a glycerinated gelatin
Polyethylene glycol via fusion or a water soluble base
I’m going to guess it’s a water soluble base, not sure which one because I still got a lot to learn
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It’s not that 
FWIW, one of the soluble bases like soluscience might be worth pursuing but I have no personal experience with that
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