Jones Reagent

[GPE]

Topic of discussion, you can search Jones Reagent and nothing shows up on this site

I’d like to know if anyone has had progress/success with Carboxylating delta 9 distillate?

I understand this is a very IP subject and don’t expect SOP’s. Just hearing about any success would give me the motivation to start some projects with it.

It would be equally great to see this being discussed

[Sidco_Cat]

Recarboxylation

Hi Everyone, I was wondering if anyone had any useful info about recarboxylation of THC—> THCA. I had an interesting project I want to explore!

Cannabinoid Carboxylation

Would anybody be interested in buying a detailed SOP for the carboxylation of cannabinoids? It’s not a terribly complicated set of reactions, though it is definitely organic chemistry. It uses way less noxious reagents than the current CBN methods many people are rocking, so I feel like the community can hang. I’ve personally used this procedure to carboxylate kilos of CBG --> CBGA. Works even better for CBD --> CBDA. Future has been encouraging me for quite some time to post about this, so I…

Recarboxylation Method: CBDA, CBGA Converted cannabinoids method

Selling recarboxylation method. Message for more details No money changes hands until you see the method in action.

[PolyC]

The jones reagent would convert delta-9 THC into the quinone (i.e d9THCQ). Once there, how do you plan on carboxylating? Conjugate addition of cyanide followed by alkaline hydrolysis? You would have to get pretty good steric control to modulate your regiochemistry. And then you’d have to reduce it back to THC again after that.

There is some literature on recarboxylation from Mechoulam. Can’t find it at the moment but it uses something akin to a Grignard reagent. Efficiency is low, <20%.

Good luck!!