So I have a lady friend and I trust what she tells me about 80% of the time. She claims she cant get high from edibles either, and that she researched and found about 1/20 people lack the enzymes to metabolize into 11-hydroxy/norcarboxy.
She also claims (wildly) that she gets rocked from certain transdermal patches. Which I dont understand because phytocannabinoids typically have a very low transdermal bioavailability… I can agree that there probably is some localized effect, but she is the only person I’ve ever met who says she gets high from a patch…
So when you consume THC, you do not get high of THC. Pretty much all the THC gets converted to 11-OH-THC which gives a different type of high as smoking and is typically considered stronger.
However, other metabolites are also reported. 8a-OH-THC and 8b-THC for example. These have no affinity for the CB1 receptor and are therefore not psychoactive. I believe some folks have a mutation that results in first pass metabolism pretty much destroying all psyhoactivity by converting the THC to 8a and 8bTHC instead of 11-OH-THC.
Sometimes this can be caused by medications a person is taking that use the same receptors. Opiates, SSRIs, MAOis and such. For those it may take some effort and for those it is worth the effort because cannabis is a better medication for them than that other crap. I’ve helped a few people through that successfully and some have stopped the meds, even. These folks didn’t have any physical obstacles like enzymes or other digestive issues, just the chemical ones.
Another sometime fix can be to use a different infusion medium. Sugars, alcohol, glycerin use other routes than lipids and they can be quite effective. Maybe not as much 11-hydroxy but it can still be formidible.
So my scientific R&D team is a group of neuroscientests who have a company of their own called Strain Genie.
It’s basically a DNA/Genetics company for cannabis. You take a swab like 23&Me and get back a 300 page report on your bodies endocannabinoid system. Including which products will work best, if you have any genetic markers that would make some type of products not work as well (IE edibles)
If you’ve already done a swab with one of the big companies you can actually upload you data and get a report back (that’s the cheapest way) don’t know if you will get a solution on how to fix the issue or not but you may be able to identify it
Yeah I’m not sure but I think if you already have a swab on file with 23 or ancestory or any of the big dna companies you can just share access and the price drops down considerably
To the OP, in the times I have talked to them about what they identify as the biggest problem with edible efficiency. They have told me some people carry certain enzymes in the liver that block the conversion