D8 in revurse

Ok next challenge those that have any info please share
I would like to do a Cbd isomerization in revurse so
Cbd D9 > Cbd D8 > THC D8
Want to find a good substitute for the solvent HMPA and parameters in Wich these rxn work

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Confused

Cbd as we know it is Cbd delta 9
By first isomerizing the cbd to Cbd delta 8
And then to thc delta 8 we might find new methods

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Get some base liable alcohol protection groups and do an acid reaction as normal? Use acid reagents that have no appreciable reaction with alkenes

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Are you implying that a sort of memory exists)

Has anyone prepared d8 cbd yet? I haven’t seen it

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I feel like I’ve been making it accidentally for a while now :joy_cat: but that’s just a guess

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Have you considered TPPA

https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201101830

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Maybe a phase transfer catalyst? That could help enhance an sn2 reaction without hmpa and use a less scary base.

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Some Cbd s are psycho active :wink:

I don’t doubt that… It’s definitely a compound I’d be interested in seeing. I take it you’ve seen it? I don’t know a method for preparing it off the top of my head.

No it s still legend Adams fed it to the rhesus monkeys and reported they behaved as in thc :grin:

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Are those the monkeys with a candy shell and peanut butter filling?

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