Hello everyone, I’m trying an efficient way to convert cbd isolate into delta 9 or as much thc as possible, regardless of whether it’s 8 or 9, I’m using a sop that a member of the group passed me, but I’m having a small problem with some batches that I imagine that the conversion is not being done correctly although I am following the steps strictly, I would like to know if someone here in the group has a SOP for delta 9 that I can try to see if I can achieve quantities higher than thc .
thanks to allMethod Ethanol.pdf (68.3 KB)I leave the SOP above so if anyone wants to read it.
woof, don’t use that method. Sulfonic acids aren’t particularly great for achieving d9, but they do good work at producing d8. Don’t use sulfonic acids and alcohols if you want to avoid getting cancer, dont do chemistry in buckets like that (which makes no sense to drop the material out of a reactor and workup in buckets by hand, just work it up in the reactor). That workup is also missing a crucial step - removing your catalyst. How do you get rid of acid? Hit it with base.
If you already own a bunch of ptsa, you could try this reactor at like 5-10 volumes heptane at like 0C and see if you can get like 50/50 d8/d9.
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Can you elaborate on this? I’ve seen it said that it creates mutagens, but I’d like to read more about the specifics
I used the Ill NYE one and modified it.
My changes were mix 4L of hexane with 1kg cbd isolate then add 1-5% PTSA in a reactor for 4-6 hours then wash it with water with baking soda and salt then straight water. After a few hours at room temperature or whatever the reaction gets to (I use a chiller with the pump on but no chill, just something to absorb the heat), and no need to pull a vacuum… all of the cbd should be d8/d9
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Do you have a SOP with the most detailed method?
Could you explain your method in more detail?
in relation to the conversion times, and if you have any SOP in detailed pdf
“Sulfonic acid esters are considered as potentially alkylating agents that may exert genotoxic effects in bacterial and mammalian cell systems. One possible source of human exposure stems from drug synthesis when the salt-forming agents methanesulfonic acid, benzenesulfonic acid or p-toluenesulfonic acid are used together with alcoholic solvents such as methanol, ethanol and propanol”
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Errrm, I am a consultant - hmu privately if you think you could use some help. Again, if d9 was my target I wouldnt use sulfonic acids because its going to make considerable d8. But if you don’t care about having a ratio of d8/d9 - run the rxn dilute/cold in heptane, and perform a proper workup to remove your catalyst.
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what is the rxn?
I wonder if op is going to make bm thc carts? yikes
This is why d8 is bad. For all the guys doing it ‘right’ (I say that loosely), there’s probably dozens of people following a rudipooh doodood8 sop.
Acids in ethanol. I’m sure that’s wiiidely used despite a quick google search telling you reacting acids in alcohols period is generally a bad idea because of all of the side reactions and even the possibility to create poison.
people are buying d8, or worse making it in buckets, and selling it as bm d9 in edibles , carts , etc. for a quick buck. Aka mammon dick riders Lol
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Again, I do this work for a living. If you believe you could use some help, send a DM and we can discuss further. But I can’t just hand out reaction conditions and written procedures or else I don’t eat lol
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It’s better and easier to do cbd > d8 > d9 conversion. Granted it’s more time consuming as it is 3 step / 3 solvents reaction chain and in between and after proper washing and distillation is required.
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What?
I’ve never heard of d8 to d9, only the inverse.
Can you provide some documentation? I thought d8 was a more stable molecule?
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It’s hard to do a one pot conversion due to acidic conditions of the rection. D9 doesn’t like it and turns in to d8. So why bother? Use the best method for full cbd-d8 conversion (acetic acid at 5C in few h gives nearly 90% conversion with only 3 byproducts.)
By the time it’s washed and disstilled it’s over 95% d8 with some cbt and exo-thc.
Next step is reaction to turn d8 to a very stable and legal intermediary and after another wash and distillation you can turn it in to D9.
Wash, distillation and you end up with nice, stable D9 as long as the ph is still slightly above 7.
I think with some tweaking last step could be modified to keep adding hydrogens but didn’t get that far yet.
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There are likely notably more byproducts (eg iso-thc), but cbt and exo-thc are the only one identified with crms.
Are you suggesting a hydrogenation /dehydrogenation process with either HHC or CBN as an intermediary ? 
There are likely notably more byproducts (eg iso-thc), but cbt and exo-thc are the only one identified with crms.
Probably but in a very small quantity.
Are you suggesting a hydrogenation /dehydrogenation process with either HHC or CBN as an intermediary ?
Intermediary converts directly to D9.
The whole process is divided in to easy to manage steps:
Acid catalysed conversion > Halogenation > Halogen substitution with double bond flipping and then possibly hydrogenation but didn’t get that far yet.
There is some solvent juggling (acetic acid, DCM, toluene) but everything can be done at room temp and without pyrophorics, organometallics, high pressure or gaseus hydrogen.
My goal is to use fairly safe chemicals and reaction parameters even at a cost of time. I think I could combine last two steps using different solvent that at the same time would work as a catayst for the last step but I’m wainting for a delivery to be able to test it. Starting with ptsa way, one could combine first two steps. But at a cost of possibly more side reactions.
One issue I have is the catalyst for the last step. It’s quite expensive and technically speaking could be used as a recreational drug or a rape pill. I don’t think it’s on any lists yet but apparently it started to be abused and it’s just a matter of time when ordering it in larger quantities could raise some eyebrows.
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I suppose so…
I’d also assume it’s pretty hard to commit more than one date rape at a time… But that’s government for yah.
Is it going to require dry sparged conditions?
I prefure gaseous hcl for the d8 making it s the highest yielding route for D8 and
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According to chromatograms acetic acid gives the least byproducts but using HCL allows to go straight to halogenation after adding the catalyst when conversion is done but it will not be so clean and I suspect lower yeld.
Ptsa is easy but even at room temp there is some polymerization happening. But the junk can easily be removed by distillation. Also it’s the fastest. 2h @ 110 in toluene gives full conversion.
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