I visited a lab today that had an interesting method for cleaning up their isolate post crystallization.
They took their powder, which looked to be lightly cleaned with cold pentane (still had residual oleoresin based on color) over a Buchner, and then added it to a beaker with hot water and overhead mixing to break up all of the chunks/crystals. They then filtered it over a Buchner and rinsed with a solvent that was miscible in water but easier to dry. I think it may have been acetonitrile?
Anyways, what do you guys think about this as an alternative to recrystallization in pentane? Has anyone used acetonitrile with cannabinoids? I’m a little skeptical to try this because I don’t know about the solubility, but I bet this would be a great way to ensure minimal residual solvent.