CBD Crystallization - reactor vessel, how large is too large?



Is there a point of diminishing returns when increasing your reactor size (ie going form 50 to 100L or 100L to 200+)? I talked to a few folks that have said they are not fans of anything larger than 20L for isolation purposes (reaction time, kinetics, and chillers/heater sizing are a few reasons they gave), and others that have commissioned custom 100L glass vessels for isolation.

I am looking at my options for scaling and would love any input. I am currently looking at several 50L or 100L units. Once the SOP’s have been thoroughly field tested and validated with the glass reactors I’d look to scale into large 200L + SS reactors. Your thoughts are greatly appreciated.