Cannabinoid and Terpene Chirality

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So, looks like new studies are coming out, I’m sure more will follow. I have been wondering about this for awhile, but I don’t like bringing up concepts without some sort of backing.

Credit to @theyogibear for this one: https://sci-hub.se/https://pubmed.ncbi.nlm.nih.gov/32591428/

All you conversion/synthetic chemists and terpene companies might have to pony up soon lol

All I mean by that is, is anyone doing anything to ensure they’re not flipping the spin on these molecules?

I want to tag some people I know are doing conversion chemistry but don’t wanna put anyone on the spot. I hope you all will just give your perspective here.

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I wonder what flips these molecules… Would be curious if even smoking or vaping something flips anything too. Or even if any kind of gc/HPLC could even test for it.

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Anyone here using chiral HPLC or GC columns? Or maybe Europium chiral shift reagents in their NMR tubes? Not sure if that phenol is close enough to a chiral center to see twinning peaks…

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There are definitely methods for chiral chromatographic separation. Supposedly SFC is very good for this

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I can’t say much.

There is a difference between natural and synthetic noids.

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People use enantiomer loosely here, not knowing the chemistry. If a compound has multiple chiral centers, all of them must be flipped at once to give an indistinguishable enantiomer. Otherwise a diastereomer is produced, which can be separated by ordinary methods. Knowing the mechanism by which your reaction operates, one could infer whether this can happen or not.

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